Notice of all temporary appointments shall be filed with the Commission prior to receipt of the payroll upon which the salary of such temporary appointee appears for approval. A vacancy in a permanent position caused by resignation of which the appointing authority has had prior notice sufficient to permit a permanent appointment shall not be filled by a temporary or emergency appointment. Where positions are rendered vacant for temporary and indefinite periods by reason of sickness of regular employees, and the Commission is unable to certify from appropriate eligible lists for such temporary and indefinite period, interim appointments without regard to the Rules and Regulations of the Commission may be authorized by the Commission during such period of sickness or disability.